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Biggest Penny Stock Gainers

This is a list of the biggest penny stock gainers today with trading volume of at least 50,000. These penny stocks are stocks under $5 and are listed under NYSE, NASDAQ, and AMEX. Please note while penny stocks are cheap to buy, they are very risky to trade, so please do your own research before you buy penny stocks.


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published on April 21, 2025

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Symbol Company Open High Low Close Volume Percent
SHFS SHF Holdings Inc 3.86 4.33 3.53 4.19 43M 87.89%
MKDW Mkdwell Tech Inc 0.23 0.65 0.23 0.39 40M 69.57%
EVGN Evogene Ltd Ord 1.20 1.34 1.08 1.27 20M 30.93%
PNBK Patriot National Bancorp 2.65 4.33 2.55 4.03 961K 22.87%
RSLS ReShape Lifesciences Inc. 0.46 0.49 0.37 0.38 151M 22.58%
OMH Ohmyhome Ltd 2.74 3.63 2.73 3.60 399K 21.62%
BON Bon Natural Life Ltd 0.06 0.07 0.06 0.06 8M 20.00%
SLDB Solid Biosciences Inc 2.53 3.09 2.51 3.03 3M 18.82%
GMM SPDR S&P Emerging Markets (ETF) 1.92 2.10 1.78 2.02 260K 18.82%
LXEO Lexeo Therapeutics Inc. 2.69 3.27 2.62 3.21 1M 18.45%
TSHA Taysha Gene Therapies Inc 1.23 1.48 1.22 1.45 5M 16.94%
ANTE Airnet Technology Inc 0.71 0.86 0.69 0.85 240K 16.44%
BIYA 3.25 4.46 3.10 3.71 406K 16.30%
UPC Universe Pharmaceuticals INC 3.32 5.47 3.06 4.14 3M 16.29%
EZGO EZGO Technologies Ltd 0.31 0.37 0.31 0.36 1M 16.13%
PRQR Proqr Therapeutics 1.12 1.39 1.12 1.32 841K 15.79%
IPM 1.95 2.08 1.84 1.91 1M 15.76%
FBLG FibroBiologics Inc 1.22 1.44 1.15 1.38 499K 15.00%
AZI Autozi Internet Technology [Global] Ltd Cl A 0.85 1.00 0.81 1.00 153K 14.94%
NVFY Nova Lifestyle Inc 0.67 0.82 0.67 0.77 147K 14.93%
WNW Wunong Net Technology Co Ltd 1.11 1.35 1.09 1.24 5M 14.81%
KOD Kodiak Sciences Inc 2.96 3.31 2.84 3.25 1M 14.44%
RENB Renovaro Biosciences Inc 0.34 0.41 0.34 0.40 364K 14.29%
PEPG PepGen Inc 1.32 1.54 1.28 1.52 239K 14.29%
MVST Microvast Holdings Inc 1.81 2.10 1.80 2.09 14M 14.21%
RZLT Rezolute Inc 2.76 3.50 2.75 3.14 2M 14.18%
LXRX Lexicon Pharmaceuticals, Inc 0.51 0.60 0.49 0.58 10M 13.73%
CTMX Cytomx Thera 0.65 0.77 0.65 0.75 2M 13.64%
INV Innovaro Inc. 3.20 3.64 3.01 3.60 109K 13.56%
MIST Milestone Pharmaceuticals Inc 0.89 1.03 0.88 1.01 3M 13.48%
TERN Terns Pharmaceuticals Inc 2.37 2.88 2.37 2.71 2M 12.92%
FATE Fate Therapeutics 1.10 1.39 1.10 1.25 6M 12.61%
XAGE 0.15 0.18 0.15 0.18 2M 12.50%
GUTS Fractyl Health Inc. 1.23 1.39 1.22 1.37 412K 12.30%
PRME Prime Medicine Inc 1.24 1.55 1.20 1.39 3M 12.10%
JSPR Jasper Therapeutics Inc 3.94 4.47 3.94 4.44 190K 11.84%
ZURA Zura Bio Ltd 1.21 1.39 1.21 1.37 441K 11.38%
SCKT Socket Mobile, Inc 1.13 1.29 1.13 1.28 67K 11.30%
RNAZ TransCode Therapeutics Inc 0.28 0.39 0.28 0.30 13M 11.11%
STI SunTrust Banks, Inc 0.09 0.11 0.09 0.10 2M 11.11%
ATPC Agape ATP Corp 1.97 2.10 1.80 2.07 425K 10.70%
TOI Oncology Institute Inc (The) 2.18 2.41 2.01 2.39 1M 10.65%
PYXS Pyxis Oncology Inc 0.95 1.11 0.92 1.06 743K 10.42%
RLMD Relmada Therapeutics Inc 0.30 0.34 0.30 0.32 785K 10.34%
MGNX Macrogenics 1.20 1.47 1.20 1.39 786K 10.32%
MGX Metagenomi Inc. 1.53 1.76 1.52 1.67 360K 9.87%
IVVD Invivyd Inc 0.53 0.57 0.49 0.56 3M 9.80%
SKYE Skye Bioscience Inc 1.40 1.58 1.36 1.57 567K 9.79%
CNSP Cns Pharmaceuticals Inc 0.85 0.90 0.80 0.90 179K 9.76%
SPAI Safe Pro Group Inc 2.58 2.73 2.51 2.70 56K 9.76%
ZBAO Zhibao Technology Inc. 0.87 1.16 0.85 1.02 230K 9.68%
CRBU Caribou Biosciences Inc 0.76 0.87 0.75 0.80 1M 9.59%
ALLR Allarity Therapeutics Inc 0.94 1.06 0.90 1.03 2M 9.57%
XLO Xilio Therapeutics Inc 0.74 0.82 0.74 0.82 297K 9.33%
MBRX Metabasis Therapeutics, Inc 0.87 0.99 0.86 0.95 320K 9.20%
PASG Passage Bio Inc 0.34 0.40 0.33 0.36 451K 9.09%
POWW AMMO Inc 1.43 1.57 1.43 1.56 699K 9.09%
HOVR New Horizon Aircraft Ltd 0.46 0.53 0.44 0.49 211K 8.89%
INM InMed Pharmaceuticals Inc 2.70 3.15 2.69 2.96 292K 8.82%
IMRX Immuneering Corp 1.29 1.39 1.26 1.38 121K 8.66%
ORGN Origin Materials Inc 0.61 0.65 0.60 0.65 493K 8.33%
PLBY PLBY Group Inc 0.97 1.06 0.96 1.05 354K 8.25%
SGMT Sagimet Biosciences Inc 2.29 2.67 2.29 2.39 1M 8.14%
SLNH Soluna Holdings Inc 0.67 0.78 0.65 0.67 353K 8.06%
RLYB Rallybio Corp 0.25 0.28 0.25 0.27 120K 8.00%
CMPS Compass Pathways Plc ADR 3.14 3.41 3.08 3.38 1M 7.99%
PMVP Pmv Pharmaceuticals Inc 1.02 1.13 0.97 1.10 148K 7.84%
WW Watson Wyatt Worldwide Inc 0.13 0.14 0.12 0.14 8M 7.69%
GBIO Generation Bio CO 0.39 0.46 0.38 0.42 608K 7.69%
SNYR 2.28 2.73 2.17 2.68 329K 7.63%
SURG Synergetics USA Inc 2.52 2.78 2.40 2.68 571K 7.63%
IFRX Fireman B.V. 1.04 1.15 1.02 1.14 83K 7.55%
ACET Aceto Corporation 0.56 0.57 0.51 0.57 291K 7.55%
OLMA Olema Pharmaceuticals Inc 4.38 4.82 4.31 4.75 897K 7.47%
RAY Raytech Holding Ltd. 2.58 2.75 2.50 2.74 4M 7.45%
SLGL Sol-Gel Technologies Ltd 0.54 0.80 0.51 0.59 1M 7.27%
UHG United Homes Group Inc 2.04 2.30 2.03 2.24 66K 7.18%
CTNM Contineum Therapeutics Inc. 4.61 5.00 4.35 4.95 154K 7.14%
IDAI T Stamp Inc 1.54 1.65 1.48 1.65 97K 7.14%
WIMI Wimi Hologram Cloud Inc ADR 4.11 5.48 4.11 4.50 4M 7.14%
OESX Orion Energy Systems, Inc 0.70 0.78 0.70 0.76 2M 7.04%
KYTX Kyverna Therapeutics Inc. 1.82 2.05 1.82 1.99 264K 6.99%
TNGX Tango Therapeutics Inc 1.29 1.39 1.24 1.38 375K 6.98%
ERAS Erasca Inc 1.16 1.42 1.13 1.24 2M 6.90%
PRPH ProPhase Labs Inc 0.29 0.32 0.28 0.31 1M 6.90%
SIEB Siebert Financial Corp. 3.35 3.66 3.17 3.58 184K 6.87%
LVTX LAVA Therapeutics NV 1.31 1.43 1.31 1.40 71K 6.87%
NEOG Neogen Corporation 4.50 4.82 4.46 4.69 12M 6.83%
AKTX Akari Therapeutics 1.29 1.29 1.03 1.28 91K 6.67%
GRWG Growgeneration Corp 0.90 0.98 0.88 0.97 589K 6.59%
INZY Inozyme Pharma Inc 0.91 1.00 0.90 0.98 376K 6.52%
GERN Geron Corporation 1.27 1.43 1.27 1.35 16M 6.30%
VVPR Vivopower International Plc 2.62 2.90 2.52 2.70 462K 6.30%
AMLX Amylyx Pharmaceuticals Inc 3.97 4.32 3.94 4.23 895K 6.28%
MSPR MSP Recovery Inc 2.05 2.47 2.05 2.20 265K 6.28%
INAB IN8bio Inc 0.16 0.17 0.16 0.17 397K 6.25%
TCRX Tscan Therapeutics Inc 1.45 1.61 1.36 1.53 616K 6.25%
VOR Vor Biopharma Inc 0.70 0.71 0.66 0.69 205K 6.15%
QNCX Quince Therapeutics Inc 1.04 1.06 0.99 1.05 92K 6.06%
QMMM QmMM Holdings Limited 0.65 0.79 0.64 0.72 329K 5.88%
CTSO Cytosorbents Cor 1.01 1.14 1.01 1.09 144K 5.83%
ATYR Atyr Pharma Inc 3.07 3.33 3.05 3.28 2M 5.81%
STRO Sutro Biopharma Inc 0.55 0.58 0.53 0.55 3M 5.77%
SGMO Sangamo Biosciences, Inc 0.71 0.81 0.70 0.74 4M 5.71%
SEAT Vivid Seats Inc 2.29 2.43 2.15 2.43 6M 5.65%
TLSA Tiziana Life Sciences Plc ADR 1.07 1.14 1.01 1.13 308K 5.61%
VTYX Ventyx Biosciences Inc 1.08 1.19 1.06 1.13 882K 5.61%
WORX Scworx Corp 0.54 0.61 0.49 0.57 923K 5.56%
WLGS WANG & LEE Group Inc. 0.19 0.19 0.17 0.19 2M 5.56%
MB 2.91 3.25 2.74 3.25 63K 5.52%
ACRV Acrivon Therapeutics Inc 1.83 2.07 1.76 1.91 314K 5.52%
ZNTL Zentalis Pharmaceuticals Inc 1.29 1.41 1.28 1.36 800K 5.43%
LRMR Larimar Therapeutics Inc 1.88 2.06 1.87 2.01 1M 5.24%
SAGT 2.28 2.54 2.26 2.42 67K 5.22%
REE Rare Element Resources Ltd. 2.54 2.64 2.51 2.64 76K 5.18%
FULC Fulcrum Therapeutics Inc 3.25 3.57 3.17 3.46 370K 5.17%
VFF Village Farms Intl 0.60 0.62 0.57 0.61 253K 5.17%
DENN Dennys Corporation 3.04 3.32 3.03 3.27 3M 5.14%
VOXR Vox Royalty Corp 3.44 3.57 3.41 3.55 302K 5.03%
WETH Wetouch Technology Inc 1.20 1.27 1.20 1.26 502K 5.00%
HCTI Healthcare Triangle Inc 0.20 0.21 0.20 0.21 148K 5.00%
WALD Waldencast Acquisition Corp 2.59 2.84 2.53 2.75 51K 4.96%
IGMS Igm Biosciences Inc 1.22 1.33 1.22 1.28 208K 4.92%
HRTX Heron Therapeutics 1.82 1.99 1.81 1.93 1M 4.89%
PGHL Primega Group Holdings Limited 0.40 0.43 0.40 0.43 274K 4.88%
TPET Trio Petroleum Corp. 1.23 1.29 1.20 1.29 114K 4.88%
VVOS Vivos Therapeutics Inc 2.15 2.26 2.10 2.20 70K 4.76%
RNTX 1.65 1.79 1.56 1.78 57K 4.71%
ORMP Oramed Pharma 2.16 2.28 2.13 2.25 56K 4.65%
STAK 1.71 1.99 1.65 1.82 244K 4.60%
DNUT Krispy Kreme Inc 4.12 4.36 4.02 4.34 3M 4.58%
DLHC Dlh Holdings Corp 3.47 3.73 3.33 3.68 107K 4.55%
SFHG Samfine Creation Holdings Group Ltd 0.65 0.70 0.65 0.70 56K 4.48%
EDAP EDAP TMS S 1.40 1.50 1.40 1.44 50K 4.35%
GNLN Greenlane Holdings Inc Cl A 0.23 0.25 0.23 0.24 200K 4.35%
MRKR Marker Therapeutics Inc 1.16 1.24 1.12 1.20 58K 4.35%
CANG Cango Inc ADR 3.69 3.92 3.57 3.89 262K 4.29%
LGHL Lion Group Holding Ltd ADR 3.05 3.56 2.80 3.23 434K 4.19%
EVTV Envirotech Vehicles Inc 0.25 0.26 0.23 0.25 56K 4.17%
MHLD Maiden Holdings, Ltd 0.95 1.03 0.94 1.00 244K 4.17%
TPIC Tpi Composites Inc 0.70 0.76 0.65 0.75 430K 4.17%
VERV Verve Therapeutics Inc 4.50 5.50 4.37 4.78 6M 4.14%
LGVN LogicVision, Inc 1.48 1.55 1.46 1.52 70K 4.11%
MNY MoneyHero Ltd 0.73 0.78 0.73 0.77 55K 4.05%
EDIT Editas Medicine 1.26 1.40 1.23 1.33 2M 3.91%
NB NioCorp Developments Ltd 2.87 2.99 2.51 2.95 3M 3.87%
EGHT 8x8, Inc 1.56 1.65 1.52 1.64 4M 3.80%
SGHT Sight Sciences Inc 2.61 2.78 2.51 2.76 118K 3.76%
PHIO Phio Pharmaceuticals Corp 2.71 2.85 2.58 2.83 655K 3.66%
SLRN Acelyrin Inc 2.18 2.31 2.18 2.28 1M 3.64%
KTTA Pasithea Therapeutics Corp 1.41 1.47 1.30 1.43 183K 3.62%
PRPL Purple Communications, Inc 0.57 0.59 0.57 0.58 352K 3.57%
ONCY Oncolytics Biotech, Inc 0.57 0.58 0.56 0.58 229K 3.57%
FBGL 0.55 0.64 0.50 0.58 197K 3.57%
MFI MicroFinancial Incorporated 0.53 0.59 0.52 0.59 116K 3.51%
IOBT IO Biotech Inc 0.85 0.91 0.85 0.89 68K 3.49%
BDTX Black Diamond Therapeutics Inc 1.40 1.59 1.39 1.49 1M 3.47%
AZTR Azitra Inc 0.28 0.31 0.28 0.30 259K 3.45%
DGXX 0.94 1.70 0.89 0.91 37M 3.41%
KOPN Kopin Corporation 0.91 0.98 0.88 0.93 3M 3.33%
SPWH Sportsman's Wareh 1.51 1.61 1.48 1.59 392K 3.25%
IMPP Imperial Petroleum Inc 2.46 2.57 2.44 2.54 130K 3.25%
PRZO ParaZero Technologies Ltd 0.64 0.65 0.57 0.64 472K 3.23%
SBFM Sunshine Biopharma Inc 1.50 1.59 1.21 1.29 12M 3.20%
STIM Neuronetics Inc 3.68 4.00 3.58 3.88 933K 3.19%
NMRA Neumora Therapeutics Inc. 0.64 0.68 0.63 0.66 602K 3.13%
GAIA Gaiam, Inc 3.81 4.17 3.68 4.01 82K 3.08%
SNES Senestech Inc 1.95 2.09 1.85 2.01 50K 3.08%
ELAB Elevai Labs Inc. 2.57 2.71 2.48 2.68 63K 3.08%
XRX Xerox Corporation 3.93 4.09 3.81 4.07 4M 3.04%



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